The prayer has become familiar through repetition. You still ask. You also brace for another day in which the thing you want changed remains. Paul knew that unfinished conversation: he asked three times for the thorn to be taken away.
We aren't told precisely what the thorn was. Paul tells us enough to know that he wanted relief. We can leave the unidentified part unidentified and still listen closely to the answer about grace and Christ's power.
There is room to keep asking
Read 2 Corinthians 12:7–10. Paul is learning to speak about weakness while resisting the pressure to impress people with his spiritual credentials. His account doesn't turn suffering into an achievement badge. Christ's power matters in the place Paul cannot repair for himself.
He asked for the thorn to go. That request is part of the account, too. You don't have to become embarrassed about wanting relief in order to receive help today.
Perhaps the hardest part is that today's grace doesn't tell you how long the ache will last. The passage gives no schedule. It lets us hear a man who has asked honestly and is learning to depend on Christ while the weakness remains.
Ask for help you can name
Tell God what you want changed. Then name the help that would make this day more bearable: someone to listen, a meal, a necessary appointment, a smaller load.
If another person is using this passage to tell you to accept abuse or refuse care, seek trustworthy support. Paul's account of weakness is not permission to keep someone in danger.
You may pray the same request tomorrow. You may also receive something useful before the answer looks the way you hoped. There is room for both in an honest life with God.
A question to sit with
What support do I need while I continue asking for change?
You can take this slowly.